Olfaction testing in patients with tremor‐dominant Parkinson's disease: Is this a distinct condition?
Identifieur interne : 003815 ( Main/Exploration ); précédent : 003814; suivant : 003816Olfaction testing in patients with tremor‐dominant Parkinson's disease: Is this a distinct condition?
Auteurs : William G. Ondo [États-Unis] ; Dejian Lai [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-04.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Essential Tremor (epidemiology), Female, Gait, Human, Humans, Hypokinesia (epidemiology), Hypokinesia (physiopathology), Male, Muscle Rigidity (epidemiology), Muscle Rigidity (physiopathology), Nervous system diseases, Olfaction, Olfaction Disorders (diagnosis), Olfaction Disorders (epidemiology), Olfaction Disorders (physiopathology), Parkinson Disease (epidemiology), Parkinson disease, Parkinson's disease, Severity of Illness Index, Tremor, essential tremor, olfaction.
- MESH :
- diagnosis : Olfaction Disorders.
- epidemiology : Essential Tremor, Hypokinesia, Muscle Rigidity, Olfaction Disorders, Parkinson Disease.
- physiopathology : Hypokinesia, Muscle Rigidity, Olfaction Disorders.
- Aged, Female, Gait, Humans, Male, Severity of Illness Index.
Abstract
There is considerable controversy regarding the relationship between essential tremor (ET) and Parkinson's disease (PD), especially when tremor is the dominant feature of PD or there is a family history of tremor. Reduced olfaction function is one of the initial signs of PD. In contrast, ET has relatively preserved olfaction. To infer whether the tremor‐dominant subgroup of PD is intrinsically different from mainstream PD, we tested olfaction using the University of Pennsylvania Smell Identification Test‐40 (UPSIT) in this group and compared the findings with those of patients with non–tremor‐dominant “regular” PD. We then evaluated predictors of reduced UPSIT scores within the tremor‐dominant group. Overall, olfaction did not differ between tremor‐dominant PD and regular PD; however, the subgroup of tremor‐dominant PD with a family history of tremor had less olfaction loss than those without a family history (P = 0.0007) or those with regular PD (P = 0.0350). Other clinical features of this tremor‐dominant PD with a family history of tremor group mostly resembled those without a family history. This finding suggests that patients with a family history of tremor may represent a different disease process even though, aside from differences in olfaction, they are clinically similar to other patients with tremor‐dominant parkinsonism. It additionally suggests phenotypic overlap between PD and ET. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20365
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-04">2005-04</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="471">471</biblScope><biblScope unit="page" to="475">475</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">90F8D4CCF1A95F49BC4EEE16BB8FA0D36991B48F</idno><idno type="DOI">10.1002/mds.20365</idno><idno type="ArticleID">MDS20365</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Essential Tremor (epidemiology)</term><term>Female</term><term>Gait</term><term>Human</term><term>Humans</term><term>Hypokinesia (epidemiology)</term><term>Hypokinesia (physiopathology)</term><term>Male</term><term>Muscle Rigidity (epidemiology)</term><term>Muscle Rigidity (physiopathology)</term><term>Nervous system diseases</term><term>Olfaction</term><term>Olfaction Disorders (diagnosis)</term><term>Olfaction Disorders (epidemiology)</term><term>Olfaction Disorders (physiopathology)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Severity of Illness Index</term><term>Tremor</term><term>essential tremor</term><term>olfaction</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypokinesia</term><term>Muscle Rigidity</term><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Olfaction</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">There is considerable controversy regarding the relationship between essential tremor (ET) and Parkinson's disease (PD), especially when tremor is the dominant feature of PD or there is a family history of tremor. Reduced olfaction function is one of the initial signs of PD. In contrast, ET has relatively preserved olfaction. To infer whether the tremor‐dominant subgroup of PD is intrinsically different from mainstream PD, we tested olfaction using the University of Pennsylvania Smell Identification Test‐40 (UPSIT) in this group and compared the findings with those of patients with non–tremor‐dominant “regular” PD. We then evaluated predictors of reduced UPSIT scores within the tremor‐dominant group. Overall, olfaction did not differ between tremor‐dominant PD and regular PD; however, the subgroup of tremor‐dominant PD with a family history of tremor had less olfaction loss than those without a family history (P = 0.0007) or those with regular PD (P = 0.0350). Other clinical features of this tremor‐dominant PD with a family history of tremor group mostly resembled those without a family history. This finding suggests that patients with a family history of tremor may represent a different disease process even though, aside from differences in olfaction, they are clinically similar to other patients with tremor‐dominant parkinsonism. It additionally suggests phenotypic overlap between PD and ET. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name></region><name sortKey="Lai, Dejian" sort="Lai, Dejian" uniqKey="Lai D" first="Dejian" last="Lai">Dejian Lai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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